In many mammalian cell types, increases in the level of nonpolymerized tubulin cause an inhibition in tubulin synthesis which is accompanied by a decrease in tubulin mRNA levels. To see whether inhibition is caused by nuclear or cytoplasmic events, two groups have recently examined the ability of enucleated cells to autoregulate tubulin synthesis.1,2 These experiments have demonstrated that transcription, processing, and transport of tubulin mRNAs from the nucleus to the cytoplasm are not major sites of autoregulation. Instead, monomeric tubulin must (...) reduce, either directly or indirectly, the translatability of its own message. (shrink)

Computational models of semantic memory exploit information about co-occurrences of words in naturally occurring text to extract information about the meaning of the words that are present in the language. Such models implicitly specify a representation of temporal context. Depending on the model, words are said to have occurred in the same context if they are presented within a moving window, within the same sentence, or within the same document. The temporal context model (TCM), which specifies a particular definition of (...) temporal context, has proved useful in the study of episodic memory. The predictive temporal context model (pTCM) uses the same definition of temporal context to generate semantic memory representations. Taken together pTCM and TCM may prove to be part of a general model of declarative memory. (shrink)

ABSTRACTOther people’s emotional reactions to a third person’s behaviour are potentially informative about what is appropriate within a given situation. We investigated whether and how observers’ inferences of such injunctive norms are shaped by expressions of anger and disgust. Building on the moral emotions literature, we hypothesised that angry and disgusted expressions produce relative differences in the strength of autonomy-based versus purity-based norm inferences. We report three studies using different types of stimuli to investigate how emotional reactions shape norms about (...) potential norm violations, and contexts. Consistent with our theoretical argument, the results indicate that observers use others’ emotional reactions not only to infer whether a particular behaviour is inappropriate, but also why it is inappropriate: because it primarily violates auto... (shrink)

In their recent article "Ideology in Action" in this journal, Alan Fine and Kent Sandstrom (1993) offer a theoretical account of ideology informed by pragmatism and symbolic interactionism. The authors provide compelling reasons for understanding ideology not simply as beliefs but as situated social action. Their effort to retrieve the analysis of ideology from the realm of the noosphere is a welcome departure from more traditional conceptions. Moreover, they provide a convincing case for bringing ideological analysis back into many of (...) our analyses of social life. In the following pages I wish to engage the authors on the terrain they have laid out. Drawing on the linguistic turn in recent social theory, I offer a few friendly critiques of their interactionist conception of ideology. After reviewing these problems I discuss how a dialogic analysis of ideology can build on Fine and Sandstrom's important account of ideology, as well as offering additional insights into its nature and dynamics. I begin, however, with a capsule review of the authors' conception of ideology in action. (shrink)

Although convergence in emotion expressions within small groups is well documented, the motives that explain why members converge are rarely explicated. We approach expressive convergence from a conformity perspective and introduce the Emotional Conformity Framework, in which we posit that members match their groupmates’ emotion expressions because they are motivated to gain an accurate understanding of reality (informational conformity motive) or to form and maintain social relationships (normative conformity motive). These motives determine members’ standards for correctness, social responses, and plausible (...) convergence mechanisms, while members’ personalities and situational properties shape the relative strength of the two motives. By explicating these motivational underpinnings, the Framework improves our capacity to understand, predict, and regulate expressive convergence and emphasizes its functionality. (shrink)

The notion that emotional expressions regulate social life by providing information is gaining popularity. Prior research on the effects of emotional expressions on observers’ inferential processes has focused mostly on inferences regarding the personality traits of the expresser, such as dominance and affiliation. We extend this line of research by exploring the possibility that emotional expressions shape observers’ construal of social situations. Across three vignette studies, an interaction partner's expressions of anger, compared to expressions of happiness or disappointment, led observers (...) to construe hypothetical situations as less cooperative, both in dyads and groups. These effects occurred even when factual information regarding the cooperativeness or competitiveness of the situation was provided, attesting to the power of emotional expressions in shaping the construal of social situations. Results are discussed in relation to appraisal theory, reverse appraisals, emotions as social information theory, and the emergence of cooperation in groups and cultures. (shrink)

Is life plausible? WeU, it's more than plausible, it has actually happened! What we need to ask, rather, is whether our explanations for how life came about and diversified are plausible. So the title of Marc W. Kirschner and John C. Gerhart's book implies the wrong question. Despite that. The Plausibility of Life makes for informative and enjoyable reading, and the issues the authors raise are worthy of attention.

Sussman and colleagues provide no evidence supporting their claim that the human vocal production system is specialized to produce locus equations with high correlations and linearity. We propose the alternative null hypothesis that these features result from physical and physiological factors common to all mammalian vocal tracts and we recommend caution in assuming that human speech production mechanisms are unique.

This collection of 24 readings is the first comprehensive treatment of important topics by leading figures in the rapidly growing interdisciplinary field of...

Experiential evidence shows that pain is associated with common meanings. These include a meaning of threat or danger, which is experienced as immediately distressing or unpleasant; cognitive meanings, which are focused on the long-term consequences of having chronic pain; and existential meanings such as hopelessness, which are more about the person with chronic pain than the pain itself. This interdisciplinary book - the second in the three-volume Meanings of Pain series edited by Dr Simon van Rysewyk - aims to better (...) understand pain by describing experiences of pain and the meanings these experiences hold for the people living through them. The lived experiences of pain described here involve various types of chronic pain, including spinal pain, labour pain, rheumatic pain, diabetic peripheral neuropathic pain, fibromyalgia, complex regional pain syndrome, endometriosis-associated pain, and cancer-related pain. Two chapters provide narrative descriptions of pain, recounted and interpreted by people with pain. Language is important to understanding the meaning of pain since it is the primary tool human beings use to manipulate meaning. As discussed in the book, linguistic meaning may hold clues to understanding some pain-related experiences, including the stigmatisation of people with pain, the dynamics of patient-clinician communication, and other issues, such as relationships between pain, public policy and the law, and attempts to develop a taxonomy of pain that is meaningful for patients. Clinical implications are described in each chapter. This book is intended for people with pain, their family members or caregivers, clinicians, researchers, advocates, and policy makers. (shrink)

Despite the recent emergence of many new ethical decision making models, there has been minimal emphasis placed on the impact of escalating commitment on the ethical decision making process. In this paper a new variable is introduced into the ethical decision making literature. This variable, exposure to escalation situations, is posited to increase the likelihood that individuals will choose unethical decision alternatives. Further, it is proposed that escalation situations should be included as a variable in Jones's (1991) comprehensive model of (...) ethical decision making. Finally, research propositions are provided based on the relationship between escalating commitment and the ethical decision making process. (shrink)

When people are performing a task, it is hard to know whether they are about to make a mistake. Klaproth, Halbrügge, Krol, Vernaleken, Zander, and Russwinkel address this by recording EEG signals while people are performing a flight control task, and show that by examining the EEG signal they can determine when people failed to notice particular stimuli, which could lead to better assistive tools.

Millikan's account of substance concepts fails to do away with features. Her approach simply moves the suite of relevant features into an encapsulated module. The crux of the problem for scientists studying human infants and nonhuman animals is to determine how individuals reidentify objects and events in the world.

Counterfactuals all the way down? Content Type Journal Article DOI 10.1007/s11016-010-9437-9 Authors Jim Woodward, History and Philosophy of Science, 1017 Cathedral of Learning, University of Pittsburgh, Pittsburgh, PA 15260, USA Barry Loewer, Department of Philosophy, Rutgers University, New Brunswick, NJ 08901, USA John W. Carroll, Department of Philosophy and Religious Studies, North Carolina State University, Raleigh, NC 27695-8103, USA Marc Lange, Department of Philosophy, University of North Carolina at Chapel Hill, CB#3125—Caldwell Hall, Chapel Hill, NC 27599-3125, USA Journal Metascience (...) Online ISSN 1467-9981 Print ISSN 0815-0796 Journal Volume Volume 20 Journal Issue Volume 20, Number 1. (shrink)

This chapter contains sections titled: Types of Knowledge in Technology A Neglected Topic Empirical Studies Philosophical Explorations References and Further Reading.